Morphine Regulates Dopaminergic Neuron Differentiation via miR-133b
نویسندگان
چکیده
منابع مشابه
Morphine regulates dopaminergic neuron differentiation via miR-133b.
Morphine is one of the analgesics used most to treat chronic pain, although its long-term administration produces tolerance and dependence through neuronal plasticity. The ability of morphine to regulate neuron differentiation in vivo has been reported. However, the detailed mechanisms have not yet been elucidated because of the inability to separate maternal influences from embryonic events. U...
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Midbrain dopaminergic (mDA) neurons control movement and emotion, and their degeneration leads to motor and cognitive defects in Parkinson's disease (PD). miR-133b is a conserved microRNA that is thought to regulate mDA neuron differentiation by targeting Pitx3, a transcription factor required for appropriate development of mDA substantia nigra neurons. Moreover, miR-133b has been found to be d...
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Mary P. Heyer,1,2 Amar K. Pani,3 Richard J. Smeyne,3 Paul J. Kenny,2 and Guoping Feng1,4 1Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, 2Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, Jupiter, Florida 33458, 3Department of Developmental Neurobiology, St. Jude Children’...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2010
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.110.066837